Objective. To evaluate the effectiveness of allogeneic fibroblasts in the treatment of chronic trophic ulcers of the lower extremities.

Material and methods. Treatment of 3 patients with chronic ulcers of lower extremities was analyzed. Allogeneic fibroblasts were obtained from the cell bank.

Results. Allogeneic fibroblasts improved the engraftment of an autologous skin graft in patients with large trophic ulcers of the lower extremities after previous unsuccessful standard therapy including vacuum therapy. Skin autoplasty was failed too. Allogeneic fibroblasts were used before plastic closure of the wound with a split-thickness skin autograft. Complete adaptation of the skin graft was observed after 14—15 days. Thus, this technique made it possible to reduce the time of graft healing by 5—7 days. In one case, skin autoplasty with partial adaptation of the flap and formation of several skin fistulous pathways were performed with high risk of limb amputation. Application of allogeneic fibroblasts ensured wound healing and preservation of the remaining skin flap. No amputations were required.

Conclusion. Allogeneic human fibroblasts together with autologous dermoplasty stimulates epithelization and reduces the risk of complications in patients with chronic ulcers of lower extremities.

Keywords. trophic ulcer, autodermoplasty, dermal fibroblasts, cell therapy